In this 2nd edition we focus on the informal economy as more than 60% of the world’s population is in the informal economy. Approximately 90% of the world’s informal employment is in the emerging and developing countries, and the total number of vulnerable workers is estimated around 2 billion. The majority of workers are vulnerable and carry the largest work-related disease burden. The 60th World Health Assembly mandated the World Health Organizarion (WHO) through the Global Plan of Action on Workers’ Health (WHA60.29) to provide basic occupational health services to workers in the informal economy. Given WHO’s unique mandate, reach, and convening power, it’s ideally placed to advance the global health agenda for workers in the informal economy.