Author(s): M. Gulumian, B. Kelman, JS Choi, CH Kim, IJ Yu

Source: Journal of  Cardiology and Vascular Medicine 2020; Vol 6: 204

Abstract: Epidemiological studies suggest that air pollutants such as fine particulate matter (PM2.5) or ultrafine particles (UFP) (PM0.1) are responsible for cardiovascular and pulmonary adverse effects following both short-term and long-term exposures. One of the potential mechanisms may be adverse effects on blood coagulation. Because nanoparticles and ultrafine particles share a similar size range, nanoparticles may act as ultrafine particles. Silver nanoparticles (AgNPs) have been extensively used nanomaterials in consumer products and medical devices. Blood coagulation effects of long-term AgNP exposure via various routes have not been studied at all. We have analyzed our seven subacute to subchronic silver nanoparticle exposure studies conducted from 2008 to 2020 at various doses in healthy rats to investigate the effects of AgNP exposure on blood coagulation. Seven silver nanoparticle (AgNP) exposure studies including two subacute oral, one subchronic oral, one subacute inhalation, one subchronic inhalation, and two subacute intravenous injections, were analyzed. Among the seven studies, only one oral subacute study showed a significant effect on active partial thromboplastin time (aPTT) in the high dose female rats, and one subacute inhalation study showed significant effects on a PTT in all concentration groups in male rats compared to that for the control. Other studies did not show any nanoparticle exposure to relevant dose-dependent effects on blood coagulation. Therefore, the effect of subacute and subchronic exposure to AgNP on blood coagulation in the healthy rat is not clear yet.

Keywords: blood coagulation; silver nanoparticles; nanoparticles; subacute; subchronic exposure; long-term exposure