Scientific Publications

February 25, 2019

Immunity to the Dual Threat of Silica Exposure and Mycobacterium tuberculosis

Authors: Petr Konecny, Rodney Ehrlich, Mary Gulumian and Muazzam Jacobs Source: Frontiers in Immunology 9:3069; DOI: 10.3389/fimmu.2018.03069 Summary: Exposure to silica and the consequent development of silicosis are well-known health problems in countries with mining and other dust producing industries. Apart from its direct fibrotic effect on lung tissue, chronic and immunomodulatory character of silica causes susceptibility to tuberculosis (TB) leading to a significantly higher TB incidence in silica-exposed populations. The presence of silica particles in the lung and silicosis […]
February 25, 2019

Environmental health practitioners potentially play a key role in helping communities adapt to climate change

Author: Busisiwe Shezi, Angela Mathee, Wellington Siziba, Renee A. Street, Nisha Naicker et al. Source: BMC Public Health (2019) 19:54; https://doi.org/10.1186/s12889-018-6378-5 Summary: Abstract: Background: Vulnerable population groups in South Africa, especially those living in poverty, young children, women, the elderly and people with pre-existing diseases, are susceptible to new or exacerbated health threats resulting from climate change. Environmental Health Practitioners (EHPs) can play an important role in helping communities adapt to climate change health impacts, however, effective coordination of this […]
February 25, 2019

Lobar evenness of deposition/ retention in rat lungs of inhaled silver nanoparticles: an approach for reducing animal use while maximizing endpoints

Authors: Jung Duck Park, Jin Kwon Kim, mi Seong Jo, Young Hun Kim, Ki Soo Jeon, et al. Source: Particle and Fibre Toxicology (2019) 16:2; https://doi.org/10.1186/s12989-018-0286-9 Summary: Abstract: Background: Information on particle deposition, retention and clearance are important for the evaluation of the risk of inhaled nanomaterials to human health. Recent revised OECD inhalation toxicity test guidelines require to evaluate the lung burden of nanomaterials after rodent subacute and subchronic inhalation exposure (OECD 412, OECD 413). These revised test guidelines […]
September 6, 2018

Translocation of silver nanoparticles in the ex vivo human placenta perfusion model characterized by single particle ICP-MS

Author J. Vidmar, K. Loeschner, M. Correia, E. Larsen, P. Manser, A. Wichser, et al. Source Royal Society of Chemistry- Nanoscale, 2018, 10, 11980-11991 Summary Abstract: With the extensive use of silver nanoparticles (AgNPs) in various consumer products their potential toxicity is of great concern especially for highly sensitive population groups such as pregnant women and even the developing fetus. To understand if AgNPs are taken up and cross the human placenta, we studied their translocation and accumulation in the […]
September 6, 2018

Size distribution of ultrafine particles generated from residential fixed-bed coal combustion in a typical brazier

Author DM Masekameni, D. Brouwer, T. Makonese, IT Rampedi and M. Gulumian Source DOI: 10.4209/aaqr.2018.03.0105 Summary Abstract: Ultrafine particles of small mean diameter released from domestic coal combustion is an important parameter to consider as it affects air quality and human health. It is suggested that poor combustion conditions release particles of different sizes enriched with health-damaging chemicals such as polycyclic aromatic hydrocarbons. Furthermore, both smouldering and high efficient combustion conditions release particles, which are often carcinogenic. Information on fixed-bed […]