From the trenches of the mines to the new world of work, the research agenda of the NIOH has transformed overtime, but the primary goal of hazard prevention and health promotion of workers remain unchanged. The toxicological effects of novel particles and fibres has been at the forefront of our research and is reflected in this issue. So is our steadfast commitment to highlighting en-vironmental health issues as a consequence of workplace exposure. A recent study fortunately showed no association between pulmonary TB and gold mine tailing dust in a nearby community.