Toxicology

In line with the NIOH’s mission the Toxicology and Biochemistry Section is committed to promote research in collaboration with national and international scientific institutions, provide specialized services, contribute to capacity development by training and teaching toxicology to undergraduate and post graduate students, and also provide consultation to governmental departments and industry in Occupational Toxicology.

The delivery of the aforementioned functions in the section is achieved through the four specialized units namely:

Nano and Micro Particle Toxicity Unit
Genotoxicity Unit
Toxicogenomics Unit
Health Risk Assessment (HRA) Unit
 

Research

Research in the section includes the hazard identification, exposure assessment and risk assessment of both incidental and engineered particles. Particle toxicity studies make use of our fully equipped tissue culture laboratory, enabling the in vitro testing of the adverse effects of particles in a cell lines including BEAS-2B, U937, CHO, HepG2, HEK293, CaCo-2, and HaCaT cells. A number of techniques are employed in the section to determine particle uptake, toxicity, genotoxicity, oxidative stress, and gene and protein expression. Methodologies implemented in the section are kept up to date with the implementation of latest developments and technologies.
 

Training and Teaching

The section is involved in intern training and the supervision of post graduate students for MSc and PhDs. The section also organizes workshops on General Toxicology, Health Risk Assessment and Occupational Toxicology.
 

Provision of Specialized Services

Specialized Services in the section involve toxicity testing services, characterization of the properties of nano and micro particles, and the provision of risk assessments for the registration of pesticides.